Sodium dipyrone


Sodium dipyrone (metamizole) is part of the class of non-steroidal anti-inflammatory drugs (IINES), is one of the most used drugs in Brazil and does not need a prescription. In other countries such as Portugal, Mexico, Spain, Russia, among others, its use is also quite popular.
The metamizole molecule has analgesic and antithemic effect. Usually presented under the form of tablets in drops.
In some countries such as the United States and Sweden, the use of dipyrone has been banned since the 1970s due to the risk of hematological reactions such as agranulocytosis and aplastic anemia. For the same reasons most european union countries, Japan and Australia also suspended their sale. (See more in: adverse effects)


Chemical name: 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminometanossulonic

Molecule names: sodium dipyrone, sodium metamizole, sodium metasulfonate.

Trade and local names: Algirona, Anador, Analgesil, Analgex, Apiron, Conmel, Difebrile, Dipidor®, Dipigina, Dipimed, Dipiran, Dipirona Sodium (generic), Dipiroterm, Diprin, Doralex, Dorfebril, Doliran, Dorona, Lylherator®, Lomdor, Magnopyrol, Maxiliv,Neosaldina®, Nofrebrin, Novagreen, Novalgina®, Pyrofebran, Salindor, Termopirona, Termoprim, Toloxin.


The dose of 500mg to 1g is usually used for adults. Maximum dose: 4g per day.

The dose for children under 15 years will depend on weight. (See medicine package leaflet)


People over 15 years: 30 to 60 drops or 1 to 2 tablets of 500mg or 1 suppository, between 1 to 4 times a day.

For children under 15 years it is recommended to use liquid dipyrone, check the dose by the weight of the child in the package leaflet of the drug.


Pain, fever, pain, postoperative analgesic, suspected anddengue symptoms


Analgesic and anti-thermal


Its effects are due to inhibition of the synthesis of prostaglandins, prostacyclins and thromboxanes, and by the reversible and irreversible inhibition of the enzyme cyclooxygenase (COX 1 and 2). Having an effect on both the central nervous system and the peripheral nervous system.


– reddish urine (not worrying)

– blood pressure drop (hypotension), especially in people susceptible to hypotension

– hypersensitivity reaction, usually right after use, including skin reactions (hives, redness, ardor, etc.), breathing problems and blood pressure drop

– haematological reactions * (leukopenia, agranulocytosis and thrombocytopenia). Signs that may indicate these changes are: inflammations in the throat, chills, high fever and tendency to bleeding.

* In 2001 ANVISA (National Health Surveillance Agency) held a “International Panel for The Safety Assessment of Dipyrone” where it was concluded that dipyrone presents the safety and efficacy necessary to continue to be commercialized in Brazil as an MIP (non-prescription drug).

There are several studies on the risk of agranulocytosis with the use of dipyrone, it is estimated that there are 1.5 cases per million, in terms of public health, it can be considered a very low risk. Regarding the risk of aplastic anemia, studies are even more controversial, many indicate that there is no connection between the use of dipyrone and aplastic anemia.


Sodium dipyrone should not be used in cases of:

– hypersensitivity to dipyrone sodium

– certain metabolic disorders: acute intermittent hepatic porphyria (risk of seizures) and congenital deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis)

– hematopoietic diseases (anaemias, agranulocytosis, leukemias, etc.)

– hypersensitivity or anaphylactic reactions to other NSAIDs (salicylates, paracetamol , diclofenac, Ibuprofen , naproxen, etc.)

– children under 3 years old or weighing less than 5 kg (pills and drops)

– children under 4 years old or weighing less than 16 kg (suppository)


Ciclosporin: there may be a decrease in the concentration of ciclosporin with the concomitant use of dipyrone


– Dipyrone should not be taken in the first 3 and last 3 months of pregnancy. Between the 4th and 6th month it can be taken under medical guidance.

– Breast-feeding should be avoided 48 hours after using the medicine.


– 500mg tablet

– Oral solution/Drops 500mg/ml

– Solution for injection (Ampoule 2ml) 500mg/ml

– Suppository 300mg (infant) and 1’000mg (adult)


– Symptoms of intoxication or overdose with sodium dipyrone are: nausea, vomiting, abdominal pain, renal failure. Few cases present drowsiness, vertigo, convulsions, pressure drop and shorthand. In addition to the reddish urine.

– There are no antidotes, one should try to eliminate excess dipyrone ingested, and stomach washing and treatment with radioactive charcoal can be done to reduce absorption.


– In the case of the old, it is recommended to be at the risk of liver and kidney failure.

– Dipyrone should not be used chronically (for long periods) or in high doses.

Jeanne Kenney
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I’m a stylist trainer, a content creator, and an entrepreneur passion. Virgo sign and Pisces ascendant, I move easily between my dreams, the crazy world I want, and my feet on the ground to carry out my projects.

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